State police Sgt. Shawn O'Keefe says the bus carrying between 50 and 60 people crashed about 4:30 a.m. Tuesday on Interstate 65 when its driver apparently swerved to avoid a minor crash that had occurred 10 minutes earlier.
Greenwood fire Battalion Chief Chris Harrell told reporters at the scene that one person was taken to a hospital in critical condition, while four people had moderate injuries and 14 had minor injuries.
Indianapolis television stations reported the bus was operated by the Megabus line and was traveling from Atlanta to Chicago. Messages from The Associated Press to Megabus weren't immediately returned.
Both northbound and southbound lanes of I-65 could be closed for several hours as the bus became entangled in the median's cable barrier, O'Keefe said.