FORT WAYNE, Ind. (WOWO): When it comes to happiness, Midwest is best. A new study shows that the top cities in the nation with the best quality of life are mostly right in the middle of the country, and coming in at number 9, and the only city representing the Hoosier State; Fort Wayne. The list is based on a number of factors, like the price of rent, hours spent commuting to work, and the unemployment rate.